Action potential shortening through the putative β 4 -adrenoceptor in ferret ventricle: comparison with β 1 - and β 2 -adrenoceptor-mediated effects
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Serelaxin Elicits Bronchodilation and Enhances β-Adrenoceptor-Mediated Airway Relaxation
Treatment with β-adrenoceptor agonists does not fully overcome the symptoms associated with severe asthma. Serelaxin elicits potent uterine and vascular relaxation via its cognate receptor, RXFP1, and nitric oxide (NO) signaling, and is being clinically evaluated for the treatment of acute heart failure. However, its direct bronchodilator efficacy has yet to be explored. Tracheal rings were pre...
متن کاملβ-Adrenoceptor-Mediated Relaxation of Carbachol-Pre-Contracted Mouse Detrusor.
AIMS To study the β-adrenoceptor subtypes involved in the relaxation responses to (-)-isoprenaline in carbachol-pre-contracted (CCh) mouse detrusor muscle with intact and denuded mucosa. METHODS Isolated muscle strips from the urinary bladder of male C57BL6 mice or β2-adrenoceptor knockout mice were pre-contracted with CCh, 1 µM and relaxed with increasing concentrations of the β-adrenoceptor...
متن کاملβ-Adrenoceptor-mediated Relaxation of Urinary Bladder Muscle in β2-Adrenoceptor Knockout Mice
BACKGROUND AND OBJECTIVE In order to characterize the β-adrenoceptor (AR) subtypes involved in agonist-stimulated relaxation of murine urinary bladder we studied the effects of (-)-isoprenaline and CL 316,243 on tonic contraction and spontaneous contractions in detrusor strips of wild-type (WT) and β2-AR knockout (β2-AR KO) mice. MATERIALS AND METHODS Urinary bladders were isolated from male ...
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BACKGROUND Propofol may decrease myocardial contractility via actions on the beta-adrenoceptor-mediated signal transduction. The aim of this study was to evaluate the effect of propofol via beta-adrenoceptor-mediated signal transduction by measuring the tissue levels of cAMP (cyclic adenosine monophosphate). METHODS The effects of propofol on beta-adrenoceptor mediated cascades were measured ...
متن کاملRole of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice.
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1998
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0702013